MUC3A induces PD-L1 and reduces tyrosine kinase inhibitors effects in EGFR-mutant non-small cell lung cancer

The immune checkpoint ligand programmed death-ligand 1 (PD-L1) and the transmembrane mucin (MUC) 3A are upregulated in non-small cell lung cancer (NSCLC), contributing to the aggressive pathogenesis and poor prognosis. Here, we report that knocking down the oncogenic MUC3A suppresses the PD-L1 expre...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Biol Sci
Prif Awduron: Luo, Yuan, Ma, Shijing, Sun, Yingming, Peng, Shan, Zeng, Zihang, Han, Linzhi, Li, Shuying, Sun, Wenjie, Xu, Jieyu, Tian, Xiaoli, Wang, Feng, Wu, Qiuji, Xiao, Yu, Zhang, Junhong, Gong, Yan, Xie, Conghua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Ivyspring International Publisher 2021
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120466/
https://ncbi.nlm.nih.gov/pubmed/33994852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.57964
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