Full spectrum of clonal haematopoiesis‐driver mutations in chronic heart failure and their associations with mortality

AIMS: Somatic mutations in haematopoietic stem cells can lead to the clonal expansion of mutated blood cells, known as clonal haematopoiesis (CH). Mutations in the most prevalent driver genes DNMT3A and TET2 with a variant allele frequency (VAF) ≥ 2% have been associated with atherosclerosis and chr...

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Detalhes bibliográficos
Publicado no:ESC Heart Fail
Main Authors: Kiefer, Katharina C., Cremer, Sebastian, Pardali, Evangelia, Assmus, Birgit, Abou‐El‐Ardat, Khalil, Kirschbaum, Klara, Dorsheimer, Lena, Rasper, Tina, Berkowitsch, Alexander, Serve, Hubert, Dimmeler, Stefanie, Zeiher, Andreas M., Rieger, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120376/
https://ncbi.nlm.nih.gov/pubmed/33779075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ehf2.13297
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