Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo

Rationale: Endoglin, also known as CD105, is a homo-dimeric membrane glycoprotein required for angiogenesis and serves as a marker for cancer vasculature. In this study, we constructed a bispecific T-cell engager (BiTE) antibody that targets human endoglin and CD3 (hEND-CD3/BiTE). We examined BiTE b...

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Vydáno v:Theranostics
Hlavní autoři: Zhong, Liping, Shi, Wei, Gan, Lu, Liu, Xiuli, Huo, Yu, Wu, Pan, Zhang, Zhikun, Wu, Tao, Peng, Hongmei, Huang, Yong, Zhao, Yongxiang, Yuan, Yulin, Deng, Zhiming, Tang, Hongliang
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120215/
https://ncbi.nlm.nih.gov/pubmed/33995664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.53121
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