Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling

Rationale: TGFβ signaling pathway controls tissue fibrotic remodeling, a hallmark in many diseases leading to organ injury and failure. In this study, we address the role of Apilimod, a pharmacological inhibitor of the lipid kinase PIKfyve, in the regulation of cardiac pathological fibrotic remodeli...

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Publicado en:Theranostics
Autores principales: Cinato, Mathieu, Guitou, Laurie, Saidi, Amira, Timotin, Andrei, Sperazza, Erwan, Duparc, Thibaut, Zolov, Sergey N., Giridharan, Sai Srinivas Panapakkam, Weisman, Lois S., Martinez, Laurent O., Roncalli, Jerome, Kunduzova, Oksana, Tronchere, Helene, Boal, Frederic
Formato: Artigo
Lenguaje:Inglês
Publicado: Ivyspring International Publisher 2021
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120213/
https://ncbi.nlm.nih.gov/pubmed/33995670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.55821
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