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Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

Current drugs for Chagas disease have long treatment regimens with occurrence of adverse drug effects leading to poor treatment compliance. Novel and efficacious medications are therefore highly needed. We previously reported on the discovery of NPD-0227 (2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phe...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Sijm, Maarten, Maes, Louis, de Esch, Iwan J. P., Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8120161/
https://ncbi.nlm.nih.gov/pubmed/33996737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2021.608438
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