Kartogenin prevents cartilage degradation and alleviates osteoarthritis progression in mice via the miR-146a/NRF2 axis

Osteoarthritis (OA) is a common articular degenerative disease characterized by loss of cartilage matrix and subchondral bone sclerosis. Kartogenin (KGN) has been reported to improve chondrogenic differentiation of mesenchymal stem cells. However, the therapeutic effect of KGN on OA-induced cartilag...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Dis
Prif Awduron: Hou, Mingzhuang, Zhang, Yijian, Zhou, Xinfeng, Liu, Tao, Yang, Huilin, Chen, Xi, He, Fan, Zhu, Xuesong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119954/
https://ncbi.nlm.nih.gov/pubmed/33986262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03765-x
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