Knockout of miR-21-5p alleviates cartilage matrix degradation by targeting Gdf5 in temporomandibular joint osteoarthritis

AIMS: The study aimed to determine whether the microRNA miR21-5p (MiR21) mediates temporomandibular joint osteoarthritis (TMJ-OA) by targeting growth differentiation factor 5 (Gdf5). METHODS: TMJ-OA was induced in MiR21 knockout (KO) mice and wild-type (WT) mice by a unilateral anterior crossbite (U...

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Detalhes bibliográficos
Publicado no:Bone Joint Res
Main Authors: Zhang, Aobo, Ma, Shixing, Yuan, Lingyu, Wu, Shichao, Liu, Shaopeng, Wei, Xiang, Chen, Lei, Ma, Chuan, Zhao, Huaqiang
Formato: Artigo
Idioma:Inglês
Publicado em: The British Editorial Society of Bone & Joint Surgery 2020
Assuntos:
Arthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572806/
https://ncbi.nlm.nih.gov/pubmed/33231490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1302/2046-3758.910.BJR-2020-0140.R1
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