Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Despite the recent launch of tolvaptan, the search for safer polycystic kidney disease (PKD) drugs continues. Ciclopirox (CPX) or its olamine salt (CPX-O) is contained in a number of commercially available antifungal agents. CPX is also reported to possess anticancer activity. Several mechanisms of...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Radadiya, Priyanka S., Thornton, Mackenzie M., Puri, Rajni V., Yerrathota, Sireesha, Dinh-Phan, Johnny, Magenheimer, Brenda, Subramaniam, Dharmalingam, Tran, Pamela V., Zhu, Hao, Bolisetty, Subhashini, Calvet, James P., Wallace, Darren P., Sharma, Madhulika
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119220/
https://ncbi.nlm.nih.gov/pubmed/33784251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141299
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