Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Despite the recent launch of tolvaptan, the search for safer polycystic kidney disease (PKD) drugs continues. Ciclopirox (CPX) or its olamine salt (CPX-O) is contained in a number of commercially available antifungal agents. CPX is also reported to possess anticancer activity. Several mechanisms of...

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Udgivet i:JCI Insight
Main Authors: Radadiya, Priyanka S., Thornton, Mackenzie M., Puri, Rajni V., Yerrathota, Sireesha, Dinh-Phan, Johnny, Magenheimer, Brenda, Subramaniam, Dharmalingam, Tran, Pamela V., Zhu, Hao, Bolisetty, Subhashini, Calvet, James P., Wallace, Darren P., Sharma, Madhulika
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119220/
https://ncbi.nlm.nih.gov/pubmed/33784251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141299
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