Ciclopirox olamine induces ferritinophagy and reduces cyst burden in polycystic kidney disease

Despite the recent launch of tolvaptan, the search for safer polycystic kidney disease (PKD) drugs continues. Ciclopirox (CPX) or its olamine salt (CPX-O) is contained in a number of commercially available antifungal agents. CPX is also reported to possess anticancer activity. Several mechanisms of...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Radadiya, Priyanka S., Thornton, Mackenzie M., Puri, Rajni V., Yerrathota, Sireesha, Dinh-Phan, Johnny, Magenheimer, Brenda, Subramaniam, Dharmalingam, Tran, Pamela V., Zhu, Hao, Bolisetty, Subhashini, Calvet, James P., Wallace, Darren P., Sharma, Madhulika
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8119220/
https://ncbi.nlm.nih.gov/pubmed/33784251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141299
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