Propensity for somatic expansion increases over the course of life in Huntington disease

Recent work on Huntington disease (HD) suggests that somatic instability of CAG repeat tracts, which can expand into the hundreds in neurons, explains clinical outcomes better than the length of the inherited allele. Here, we measured somatic expansion in blood samples collected from the same 50 HD...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Kacher, Radhia, Lejeune, François-Xavier, Noël, Sandrine, Cazeneuve, Cécile, Brice, Alexis, Humbert, Sandrine, Durr, Alexandra
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2021
Teme:
Genetics and Genomics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118653/
https://ncbi.nlm.nih.gov/pubmed/33983118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64674
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