Propensity for somatic expansion increases over the course of life in Huntington disease

Recent work on Huntington disease (HD) suggests that somatic instability of CAG repeat tracts, which can expand into the hundreds in neurons, explains clinical outcomes better than the length of the inherited allele. Here, we measured somatic expansion in blood samples collected from the same 50 HD...

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Pubblicato in:eLife
Autori principali: Kacher, Radhia, Lejeune, François-Xavier, Noël, Sandrine, Cazeneuve, Cécile, Brice, Alexis, Humbert, Sandrine, Durr, Alexandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Genetics and Genomics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118653/
https://ncbi.nlm.nih.gov/pubmed/33983118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64674
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