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To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase

Double-stranded RNA (dsRNA) is produced both by virus and host. Its recognition by the melanoma differentiation–associated gene 5 (MDA5) initiates type I interferon responses. How can a host distinguish self-transcripts from nonself to ensure that responses are targeted correctly? Here, I discuss a...

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Sonraí Bibleagrafaíochta
Foilsithe in:PLoS Genet
Príomhúdar: Herbert, Alan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118290/
https://ncbi.nlm.nih.gov/pubmed/33983939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009513
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