Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells...

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Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Buck, Jessica, Dyer, Patrick J. C., Hii, Hilary, Carline, Brooke, Kuchibhotla, Mani, Byrne, Jacob, Howlett, Meegan, Whitehouse, Jacqueline, Ebert, Martin A., McDonald, Kerrie L., Gottardo, Nicholas G., Endersby, Raelene
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116896/
https://ncbi.nlm.nih.gov/pubmed/33996894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.633344
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