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Targeting Sphingosine-1-Phosphate Signaling in Immune-Mediated Diseases: Beyond Multiple Sclerosis
Sphingosine-1-phosphate (S1P) is a bioactive lipid metabolite that exerts its actions by engaging 5 G-protein-coupled receptors (S1PR1-S1PR5). S1P receptors are involved in several cellular and physiological events, including lymphocyte/hematopoietic cell trafficking. An S1P gradient (low in tissues...
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| Published in: | Drugs |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Springer International Publishing
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8116828/ https://ncbi.nlm.nih.gov/pubmed/33983615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40265-021-01528-8 |
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