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Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery
Allopregnanolone, a positive modulator of GABA(A) receptors with antiseizure activity, has potential in the treatment of seizure emergencies. Instillation of allopregnanolone in 40% sulfobutylether-β-cyclodextrin into the nose in mice rapidly elevated the seizure threshold in the timed intravenous p...
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| Pubblicato in: | Neurotherapeutics |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer International Publishing
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8116426/ https://ncbi.nlm.nih.gov/pubmed/33405197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-020-00985-5 |
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