Mesenchymal Stem Cells Suppress TGF-β Release to Decrease α-SMA Expression in Ameliorating CCl4-Induced Liver Fibrosis

INTRODUCTION: Liver fibrosis (LF) is the excessive deposition of extracellular matrix (ECM), produced by overactivated hepatic stellate cells, following prolonged transforming growth factor-β (TGF-β) stimulation. The ability of mesenchymal stem cells (MSCs) to improve LF has been reported. However,...

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Veröffentlicht in:Med Arch
Hauptverfasser: Hermansyah, Dedy, Putra, Agung, Muhar, Adi Muradi, Retnaningsih, Wirastuti, Ken, Dirja, Bayu Tirta
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academy of Medical Sciences of Bosnia and Herzegovina 2021
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8116080/
https://ncbi.nlm.nih.gov/pubmed/34012193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5455/medarh.2021.75.16-22
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