INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication

INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rpt1/IN-CTD interface residues overlap with those re...

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Publicat a:Nat Commun
Autors principals: Dixit, Updesh, Bhutoria, Savita, Wu, Xuhong, Qiu, Liming, Spira, Menachem, Mathew, Sheeba, Harris, Richard, Adams, Lucas J., Cahill, Sean, Pathak, Rajiv, Rajesh Kumar, P., Nguyen, Minh, Acharya, Seetharama A., Brenowitz, Michael, Almo, Steven C., Zou, Xiaoqin, Steven, Alasdair C., Cowburn, David, Girvin, Mark, Kalpana, Ganjam V.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115288/
https://ncbi.nlm.nih.gov/pubmed/33980829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22733-9
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