Leflunomide Induces Dose-Dependent Lung Injury in Mice via Stimulating Vimentin and NLRP3 Inflammasome Production

Recently, the therapeutic importance of the anti-rheumatic drug, leflunomide, has been increased after the involvement of leflunomide in treating other autoimmune diseases and its promising role in retarding human malignancies. Few studies have focused on the safety in human or animals without clear...

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Vydáno v:Front Pharmacol
Hlavní autoři: El-Sherbiny, Mohamed, Atef, Hoda, Eladl, Mohamed Ahmed, Mohamed, Abdelaty Shawky, El-Shafey, Mohamed, Ali, Howaida S., Zaitone, Sawsan A., Alomar, Suliman Y., Alqahtani, Saeed Awad M., Aloyouni, Sheka Yagub, Attia, Mohammed A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8115235/
https://ncbi.nlm.nih.gov/pubmed/33995030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.631216
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