Targeting the tumor core: hypoxia-responsive nanoparticles for delivery of chemotherapy to pancreatic tumors

In pancreatic ductal adenocarcinoma (PDAC), early onset of hypoxia triggers remodeling of the extracellular matrix, epithelial-to-mesenchymal transition, increased cell survival, the formation of cancer stem cells, and drug resistance. Hypoxia in PDAC is also associated with the development of colla...

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Veröffentlicht in:Mol Pharm
Hauptverfasser: Confeld, Matthew I., Mamnoon, Babak, Feng, Li, Jensen-Smith, Heather, Ray, Priyanka, Froberg, Jamie, Kim, Jiha, Hollingsworth, Michael A., Quadir, Mohiuddin, Choi, Yongki, Mallik, Sanku
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8114572/
https://ncbi.nlm.nih.gov/pubmed/32521162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00247
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