Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma

Colonization is believed a rate-limiting step of metastasis cascade. However, its underlying mechanism is not well understood. Uveal melanoma (UM), which is featured with single organ liver metastasis, may provide a simplified model for realizing the complicated colonization process. Because DDR1 wa...

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Publicat a:Signal Transduct Target Ther
Autors principals: Dai, Wei, Liu, Shenglan, Wang, Shubo, Zhao, Li, Yang, Xiao, Zhou, Jingfeng, Wang, Yun, Zhang, Jing, Zhang, Ping, Ding, Ke, Li, Yangqiu, Pan, Jingxuan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113510/
https://ncbi.nlm.nih.gov/pubmed/33976105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00563-x
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