CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion

CRISPR-based active genetic elements, or gene-drives, copied via homology-directed repair (HDR) in the germline, are transmitted to progeny at super-Mendelian frequencies. Active genetic elements also can generate widespread somatic mutations, but the genetic basis for such phenotypes remains uncert...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Li, Zhiqian, Marcel, Nimi, Devkota, Sushil, Auradkar, Ankush, Hedrick, Stephen M., Gantz, Valentino M., Bier, Ethan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113449/
https://ncbi.nlm.nih.gov/pubmed/33976171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22927-1
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