A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca(2+)-signalling

Methods to assess neuronal receptor functions are needed in toxicology and for drug development. Human-based test systems that allow studies on glutamate signalling are still scarce. To address this issue, we developed and characterized pluripotent stem cell (PSC)-based neural cultures capable of fo...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Klima, Stefanie, Brüll, Markus, Spreng, Anna-Sophie, Suciu, Ilinca, Falt, Tjalda, Schwamborn, Jens C., Waldmann, Tanja, Karreman, Christiaan, Leist, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
Assuntos:
In Vitro Systems
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113295/
https://ncbi.nlm.nih.gov/pubmed/33713149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-03024-0
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