Human neuronal signaling and communication assays to assess functional neurotoxicity

Prediction of drug toxicity on the human nervous system still relies mainly on animal experiments. Here, we developed an alternative system allowing assessment of complex signaling in both individual human neurons and on the network level. The LUHMES cultures used for our approach can be cultured in...

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Dades bibliogràfiques
Publicat a:Arch Toxicol
Autors principals: Loser, Dominik, Schaefer, Jasmin, Danker, Timm, Möller, Clemens, Brüll, Markus, Suciu, Ilinca, Ückert, Anna-Katharina, Klima, Stefanie, Leist, Marcel, Kraushaar, Udo
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2020
Matèries:
Organ Toxicity and Mechanisms
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811517/
https://ncbi.nlm.nih.gov/pubmed/33269408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02956-3
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