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Facile Synthesis and Antimycobacterial Activity of Isoniazid, Pyrazinamide and Ciprofloxacin Derivatives
Several rationally designed isoniazid (INH), pyrazinamide (PZA) and ciprofloxacin (CPF) derivatives were conveniently synthesised and evaluated in vitro against H37Rv M. tb strain. CPF derivative 16 displayed a modest activity (MIC = 16 μg/mL) and was docked into the M. tb DNA gyrase. Isoniazid-pyra...
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| Опубликовано в: : | Chem Biol Drug Des |
|---|---|
| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8113106/ https://ncbi.nlm.nih.gov/pubmed/33638304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13836 |
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