Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Radiotherapy is an effective option for the treatment of TNBC; however, acquired radioresistance is a major challenge to the modality. In this study, we show that the integrated stress response (ISR) is the most activ...

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Vydáno v:Redox Biol
Hlavní autoři: Bai, Xupeng, Ni, Jie, Beretov, Julia, Wasinger, Valerie C., Wang, Shanping, Zhu, Ying, Graham, Peter, Li, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111851/
https://ncbi.nlm.nih.gov/pubmed/33946018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101993
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