Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

Homozygous mutations in the lysosomal glucocerebrosidase gene, GBA1, cause Gaucher’s disease (GD), while heterozygous mutations in GBA1 are a strong risk factor for Parkinson’s disease (PD), whose pathological hallmark is intraneuronal α-synuclein (asyn) aggregates. We previously reported that gba1...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Brain
Main Authors: Nakanishi, Etsuro, Uemura, Norihito, Akiyama, Hisako, Kinoshita, Masato, Masanori, Sawamura, Taruno, Yosuke, Yamakado, Hodaka, Matsuzawa, Shu-ichi, Takeda, Shunichi, Hirabayashi, Yoshio, Takahashi, Ryosuke
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111776/
https://ncbi.nlm.nih.gov/pubmed/33971917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00790-x
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