Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

Enforcing differentiation of cancer stem cells is considered as a potential strategy to sensitize colorectal cancer cells to irradiation and chemotherapy. Activation of the unfolded protein response, due to endoplasmic reticulum (ER) stress, causes rapid stem cell differentiation in normal intestina...

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Publicat a:Sci Rep
Autors principals: Meijer, Bartolomeus J., Smit, Wouter L., Koelink, Pim J., Westendorp, Barbara F., de Boer, Ruben J., van der Meer, Jonathan H. M., Vermeulen, Jacqueline L. M., Paton, James C., Paton, Adrienne W., Qin, Jun, Dekker, Evelien, Muncan, Vanesa, van den Brink, Gijs R., Heijmans, Jarom
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111031/
https://ncbi.nlm.nih.gov/pubmed/33972635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89326-w
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