A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers

PT150, a novel competitive glucocorticoid receptor (GR) antagonist, has proven safe in animal models, healthy volunteers, and people with depression. Our study is the first to investigate PT150’s safety with alcohol use. The primary objective of this study was to evaluate pharmacodynamic interaction...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Morice, Claire, Baker, Dewleen G., Patel, Marguerite M., Nolen, Tracy L., Nowak, Kayla, Hirsch, Shawn, Kosten, Thomas R., Verrico, Christopher D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111026/
https://ncbi.nlm.nih.gov/pubmed/33972573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88609-6
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