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A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers

PT150, a novel competitive glucocorticoid receptor (GR) antagonist, has proven safe in animal models, healthy volunteers, and people with depression. Our study is the first to investigate PT150’s safety with alcohol use. The primary objective of this study was to evaluate pharmacodynamic interaction...

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Publicat a:Sci Rep
Autors principals: Morice, Claire, Baker, Dewleen G., Patel, Marguerite M., Nolen, Tracy L., Nowak, Kayla, Hirsch, Shawn, Kosten, Thomas R., Verrico, Christopher D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8111026/
https://ncbi.nlm.nih.gov/pubmed/33972573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88609-6
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