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Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin
Shiga toxin (Stx) is a major virulence factor of enterohemorrhagic Escherichia coli, which causes fatal systemic complications. Here, we identified a tetravalent peptide that inhibited Stx by targeting its receptor-binding, B-subunit pentamer through a multivalent interaction. A monomeric peptide wi...
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| Publicado en: | Commun Biol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8111002/ https://ncbi.nlm.nih.gov/pubmed/33972673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02068-3 |
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