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Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases
Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here, we clarify the ambiguous role of the related family member gasdermin E (GSDME) in this process. Inflammasome stimulation in GSD...
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| Publicado no: | Cell Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8106763/ https://ncbi.nlm.nih.gov/pubmed/33852854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108998 |
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