CXCR4 intracellular protein promotes drug resistance and tumorigenic potential by inversely regulating the expression of Death Receptor 5

Chemokine receptor CXCR4 overexpression in solid tumors has been strongly associated with poor prognosis and adverse clinical outcome. However, blockade of CXCL12-CXCR4 signaling axis by inhibitors like Nox-A12, FDA approved CXCR4 inhibitor drug AMD3100 have shown limited clinical success in cancer...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Nengroo, Mushtaq A., Maheshwari, Shrankhla, Singh, Akhilesh, Verma, Ayushi, Arya, Rakesh K., Chaturvedi, Priyank, Saini, Krishan K., Singh, Anup K., Sinha, Abhipsa, Meena, Sanjeev, Gupta, Annapurna, Mishra, Anjali, Sarkar, Jayanta, Datta, Dipak
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106681/
https://ncbi.nlm.nih.gov/pubmed/33966046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03730-8
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