Dual targeting of MDM2 with a novel small-molecule inhibitor overcomes TRAIL resistance in cancer

Mouse double minute 2 (MDM2) protein functionally inactivates the tumor suppressor p53 in human cancer. Conventional MDM2 inhibitors provide limited clinical application as they interfere only with the MDM2–p53 interaction to release p53 from MDM2 sequestration but do not prevent activated p53 from...

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Publicado no:Carcinogenesis
Main Authors: Singh, Anup Kumar, Chauhan, Shikha S., Singh, Sudhir Kumar, Verma, Ved Vrat, Singh, Akhilesh, Arya, Rakesh Kumar, Maheshwari, Shrankhla, Akhtar, Md. Sohail, Sarkar, Jayanta, Rangnekar, Vivek M., Chauhan, Prem M.S., Datta, Dipak
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6276916/
https://ncbi.nlm.nih.gov/pubmed/27543608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgw088
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