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Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells

The sonic hedgehog (Shh) pathway is highly activated in a variety of malignancies and plays important roles in tumorigenesis, tumor growth, drug resistance, and metastasis. Our recent study showed that the inhibitors of the Shh pathway such as cyclopamine (CP), a Smothened (SMO) inhibitor, and GANT6...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, Sumei, Wang, Jingxiang, Lu, Yurong, Zhao, Yuqing, Prinz, Richard A., Xu, Xiulong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106679/
https://ncbi.nlm.nih.gov/pubmed/33966040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03744-2
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