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Neuromodulator release in neurons requires two functionally redundant calcium sensors

Neuropeptides and neurotrophic factors secreted from dense core vesicles (DCVs) control many brain functions, but the calcium sensors that trigger their secretion remain unknown. Here, we show that in mouse hippocampal neurons, DCV fusion is strongly and equally reduced in synaptotagmin-1 (Syt1)- or...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: van Westen, Rhodé, Poppinga, Josse, Díez Arazola, Rocío, Toonen, Ruud F., Verhage, Matthijs
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106342/
https://ncbi.nlm.nih.gov/pubmed/33903230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012137118
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