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Neuromodulator release in neurons requires two functionally redundant calcium sensors

Neuropeptides and neurotrophic factors secreted from dense core vesicles (DCVs) control many brain functions, but the calcium sensors that trigger their secretion remain unknown. Here, we show that in mouse hippocampal neurons, DCV fusion is strongly and equally reduced in synaptotagmin-1 (Syt1)- or...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: van Westen, Rhodé, Poppinga, Josse, Díez Arazola, Rocío, Toonen, Ruud F., Verhage, Matthijs
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106342/
https://ncbi.nlm.nih.gov/pubmed/33903230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012137118
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