Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2

G protein–coupled receptors (GPCRs) play diverse roles in physiological processes, and hence the ligands to modulate GPCRs have served as important molecules in biological and pharmacological approaches. However, the exploration of novel ligands for GPCR still remains an arduous challenge. In this s...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Takahashi, Masaki, Amano, Ryo, Ozawa, Michiru, Martinez, Anna, Akita, Kazumasa, Nakamura, Yoshikazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8106294/
https://ncbi.nlm.nih.gov/pubmed/33911033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019497118
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