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Targeting Thymidine Phosphorylase with Tipiracil Hydrochloride Attenuates Thrombosis without Increasing Risk of Bleeding in Mice
OBJECTIVE: Current antiplatelet medications increase the risk of bleeding, which leads to a clear clinical need in developing novel mechanism-based antiplatelet drugs. Thymidine phosphorylase (TYMP), a cytoplasm protein that is highly expressed in platelets, facilitates multiple agonist-induced plat...
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| Publicado no: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8105268/ https://ncbi.nlm.nih.gov/pubmed/33297751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315109 |
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