Endothelial TFEB (Transcription Factor EB) Improves Glucose Tolerance via Upregulation of IRS (Insulin Receptor Substrate) 1 and IRS2

OBJECTIVES: Vascular endothelial cells (ECs) play a critical role in maintaining vascular homeostasis. Aberrant EC metabolism leads to vascular dysfunction and metabolic diseases. Transcription factor EB (TFEB), a master regulator of lysosome biogenesis and autophagy, has protective effects on vascu...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Sun, Jinjian, Lu, Haocheng, Liang, Wenying, Zhao, Guizhen, Ren, Lu, Hu, Die, Chang, Ziyi, Liu, Yuhao, Garcia-Barrio, Minerva T., Zhang, Jifeng, Chen, Y Eugene, Fan, Yanbo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105265/
https://ncbi.nlm.nih.gov/pubmed/33297755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.315310
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