Quantification of SV2A Binding in Rodent Brain Using [(18)F]SynVesT-1 and PET Imaging

PURPOSE: Synapse loss is a hallmark of Alzheimer’s Disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of n...

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Vydáno v:Mol Imaging Biol
Hlavní autoři: Sadasivam, Pragalath, Fang, Xiaotian T., Toyonaga, Takuya, Lee, Supum, Xu, Yuping, Zheng, Ming-Qiang, Spurrier, Joshua, Huang, Yiyun, Strittmatter, Stephen M., Carson, Richard E., Cai, Zhengxin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8105262/
https://ncbi.nlm.nih.gov/pubmed/33258040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-020-01567-9
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