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Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis

Spatiotemporal restriction of signaling plays a critical role in animal development and tissue homeostasis. All stem and progenitor cells in newly hatched C. elegans larvae are quiescent and capable of suspending their development until sufficient food is supplied. Here, we show that ptr-18, which e...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Chiyoda, Hirohisa, Kume, Masahiko, del Castillo, Carla Cadena, Kontani, Kenji, Spang, Anne, Katada, Toshiaki, Fukuyama, Masamitsu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104386/
https://ncbi.nlm.nih.gov/pubmed/33872306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009457
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