Single-cell genomics reveals a novel cell state during smooth muscle cell phenotypic switching and potential therapeutic targets for atherosclerosis in mouse and human

BACKGROUND: Smooth muscle cells (SMC) play significant roles in atherosclerosis via phenotypic switching, a pathological process in which SMC dedifferentiation, migration and transdifferentiation into other cell types. Yet, how SMC contribute to pathophysiology of atherosclerosis remains elusive. ME...

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Publicat a:Circulation
Autors principals: Pan, Huize, Xue, Chenyi, Auerbach, Benjamin J., Fan, Jiaxin, Bashore, Alexander C., Cui, Jian, Yang, Dina Y., Trignano, Sarah B., Liu, Wen, Shi, Jianting, Ihuegbu, Chinyere O., Bush, Erin C., Worley, Jeremy, Vlahos, Lukas, Laise, Pasquale, Solomon, Robert A., Connolly, Edward S., Califano, Andrea, Sims, Peter A., Zhang, Hanrui, Li, Mingyao, Reilly, Muredach P.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8104264/
https://ncbi.nlm.nih.gov/pubmed/32962412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.120.048378
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