Loss of the Vaccinia Virus 35-Amino-Acid Hydrophobic O3 Protein Is Partially Compensated by Mutations in the Transmembrane Domains of Other Entry Proteins

Eleven highly conserved proteins comprise the poxvirus entry-fusion complex (EFC). We focused on vaccinia virus (VACV) O3, a 35-amino-acid, largely hydrophobic component of unknown specific function. Experimental evolution was carried out by blindly passaging a virus that was severely impaired in en...

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Veröffentlicht in:J Virol
Hauptverfasser: Tak, Andrew I., Americo, Jeffrey L., Diesterbeck, Ulrike S., Moss, Bernard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2021
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103694/
https://ncbi.nlm.nih.gov/pubmed/33504600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02228-20
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