Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice

BACKGROUND: Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative dose of DOX, the mechanisms of its long-term...

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Detalhes bibliográficos
Publicado no:BMC Pharmacol Toxicol
Main Authors: Furihata, Takaaki, Maekawa, Satoshi, Takada, Shingo, Kakutani, Naoya, Nambu, Hideo, Shirakawa, Ryosuke, Yokota, Takashi, Kinugawa, Shintaro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103594/
https://ncbi.nlm.nih.gov/pubmed/33962676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40360-021-00495-w
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