The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis

The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Despite their presence, T‐cell‐directed therapies fail to elicit effectiv...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Niesel, Katja, Schulz, Michael, Anthes, Julian, Alekseeva, Tijna, Macas, Jadranka, Salamero‐Boix, Anna, Möckl, Aylin, Oberwahrenbrock, Timm, Lolies, Marco, Stein, Stefan, Plate, Karl H, Reiss, Yvonne, Rödel, Franz, Sevenich, Lisa
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103101/
https://ncbi.nlm.nih.gov/pubmed/33755340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202013412
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