LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway

OBJECTIVE: Adaptive rewiring of cancer energy metabolism has received increasing attention. By binding with LDLs, LDLRs make most of the circulating cholesterol available for cells to utilize. However, it remains unclear how LDLR works in HCC development by affecting cholesterol metabolism. METHODS:...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Chen, Ziye, Chen, Lu, Sun, Bo, Liu, Dongming, He, Yuchao, Qi, Lisha, Li, Guangtao, Han, Zhiqiang, Zhan, Linlin, Zhang, Su, Zhu, Keyun, Luo, Yi, Chen, Liwei, Zhang, Ning, Guo, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102998/
https://ncbi.nlm.nih.gov/pubmed/33823318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101230
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