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Microglia use TAM receptors to detect and engulf amyloid beta plaques

Two microglial TAM receptor tyrosine kinases - Axl and Mer - have been linked to Alzheimer’s disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer’s disease and its mouse models, induced expression of Axl and Mer in amyloid plaque-associated microglia was...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Huang, Youtong, Happonen, Kaisa E., Burrola, Patrick G., O’Connor, Carolyn, Hah, Nasun, Huang, Ling, Nimmerjahn, Axel, Lemke, Greg
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102389/
https://ncbi.nlm.nih.gov/pubmed/33859405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-021-00913-5
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