Differential expression of CD49a and CD49b determines localization and function of tumor-infiltrating CD8(+) T cells

CD8(+) T-cell infiltration and effector activity in tumors are correlated with better overall survival of patients, suggesting that the ability of T cells to enter and remain in contact with tumor cells supports tumor control. CD8(+) T cells express the collagen-binding integrins CD49a and CD49b, bu...

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Udgivet i:Cancer Immunol Res
Main Authors: Melssen, Marit M., Lindsay, Robin S., Stasiak, Katarzyna, Rodriguez, Anthony B., Briegel, Amanda M., Cyranowski, Salwador, Rutkowski, Melanie R., Conaway, Mark R., Melief, Cornelis J. M., van der Burg, Sjoerd H., Eyo, Ukpong, Slingluff, Craig L., Engelhard, Victor H.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102369/
https://ncbi.nlm.nih.gov/pubmed/33619119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0427
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