Metastasis and immune evasion from extracellular cGAMP hydrolysis

Cytosolic DNA is characteristic of chromosomally unstable metastatic cancer cells, resulting in constitutive activation of the cGAS-STING innate immune pathway. How tumors co-opt inflammatory signaling while evading immune surveillance remains unknown. Here we show that the ectonucleotidase ENPP1 pr...

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Published in:Cancer Discov
Main Authors: Li, Jun, Duran, Mercedes A., Dhanota, Ninjit, Chatila, Walid K., Bettigole, Sarah E., Kwon, John, Sriram, Roshan K, Humphries, Matthew P, Salto-Tellez, Manuel, James, Jacqueline A., Hanna, Matthew G., Melms, Johannes C., Vallabhaneni, Sreeram, Litchfield, Kevin, Usaite, Ieva, Biswas, Dhruva, Bareja, Rohan, Li, Hao Wei, Martin, Maria Laura, Dorsaint, Princesca, Cavallo, Julie-Ann, Li, Peng, Pauli, Chantal, Gottesdiener, Lee, DiPardo, Benjamin J., Hollmann, Travis J., Merghoub, Taha, Wen, Hannah Y., Reis-Filho, Jorge S., Riaz, Nadeem, Su, Shin-San Michael, Kalbasi, Anusha, Vasan, Neil, Powell, Simon N., Wolchok, Jedd D., Elemento, Olivier, Swanton, Charles, Shoushtari, Alexander N., Parkes, Eileen E., Izar, Benjamin, Bakhoum, Samuel F.
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8102348/
https://ncbi.nlm.nih.gov/pubmed/33372007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0387
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