Profiling non-small cell lung cancer reveals that PD-L1 is associated with wild type EGFR and vascular invasion, and immunohistochemistry quantification of PD-L1 correlates weakly with RT-qPCR

Most lung cancer patients are diagnosed at an advanced stage, limiting their treatment options with very low response rate. Lung cancer is the most common cause of cancer death worldwide. Therapies that target driver gene mutations (e.g. EGFR, ALK, ROS1) and checkpoint inhibitors such anti-PD-1 and...

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Publicat a:PLoS One
Autors principals: Alwithenani, Akram, Bethune, Drew, Castonguay, Mathieu, Drucker, Arik, Flowerdew, Gordon, Forsythe, Marika, French, Daniel, Fris, John, Greer, Wenda, Henteleff, Harry, MacNeil, Mary, Marignani, Paola, Morzycki, Wojciech, Plourde, Madelaine, Snow, Stephanie, Marcato, Paola, Xu, Zhaolin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101740/
https://ncbi.nlm.nih.gov/pubmed/33956842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251080
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